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A Novel Lysosome Targeting Chimera for Targeted Protein Degradation via Split-and-Mix Strategy

JOURNAL ARTICLE published 17 May 2024 in ACS Chemical Biology

Research funded by Beijing National Laboratory for Molecular Sciences (BNLMS20160112) | National Key Research and Development Program of China (2021YFC2103900) | Science and Technology Foundation of Shenzhen City (JCYJ20200109140406047,JCYJ20220818095808019,RCJC20200714114433053) | National Natural Science Foundation of China (21977010) | Natural Science Foundation of Guangdong Province (2022A1515010996) | Shenzhen-Hong Kong Institute of Brain Science (2019SHIBS0004) | National Center for Biological Medicine Technology Innovation (NCTIB2022HS01017) | Tian Fu Jin Cheng Laboratory Group Racing Project (TFJC2023010008) | High-tech Zone Development Special Project of Shenzhen (29853M-KCJ-2023-002-07)

Authors: Jinpeng Wang | Yuechen Wang | Fenfang Yang | Qinhong Luo | Zhanfeng Hou | Yun Xing | Fei Lu | Zigang Li | Feng Yin

https://doi.org/10.1021/acschembio.4c00092 Actions

mRNA Display Identifies Potent, Paralog-Selective Peptidic Ligands for ARID1B

JOURNAL ARTICLE published 17 May 2024 in ACS Chemical Biology

Authors: Gregor S. Cremosnik | Yannick Mesrouze | Patrik Zueger | David Furkert | Frédéric Grandjean | Dayana Argoti | Fanny Mermet-Meillon | Matthias R. Bauer | Scott Brittain | Phuong Rogemoser | Winnie Yang | Jerome Giovannoni | Lynn McGregor | Jenny Tang | Mark Knapp | Sandra Holzinger | Sylvia Buhr | Lionel Muller | Lukas Leder | Lili Xie | Cesar Fernandez | Cristina Nieto-Oberhuber | Patrick Chène | Giorgio G. Galli | Fabian Sesterhenn

https://doi.org/10.1021/acschembio.4c00083 Actions

Chemical Genetics in C. elegans Identifies Anticancer Mycotoxins Chaetocin and Chetomin as Potent Inducers of a Nuclear Metal Homeostasis Response

JOURNAL ARTICLE published 17 May 2024 in ACS Chemical Biology

Research funded by National Science Foundation (IOS-1452948) | U.S. Department of Health and Human Services (RM1GM145426) | University of Florida (OR-DRPD-ROF2018)

Authors: Elijah Abraham | A. M. Gihan K. Athapaththu | Kalina R. Atanasova | Qi-Yin Chen | Taylor J. Corcoran | Juan Piloto | Cheng-Wei Wu | Ranjala Ratnayake | Hendrik Luesch | Keith P. Choe

https://doi.org/10.1021/acschembio.4c00131 Actions

GS-441524-Diphosphate-Ribose Derivatives as Nanomolar Binders and Fluorescence Polarization Tracers for SARS-CoV-2 and Other Viral Macrodomains

JOURNAL ARTICLE published 17 May 2024 in ACS Chemical Biology

Research funded by National Institute of Arthritis and Musculoskeletal and Skin Diseases (R01AR078555) | National Institute of General Medical Sciences (R35GM136258)

Authors: Kewen Peng | Shamar D. Wallace | Saket R. Bagde | Jialin Shang | Ananya Anmangandla | Sadhan Jana | J. Christopher Fromme | Hening Lin

https://doi.org/10.1021/acschembio.4c00027 Actions

Reactive Oxygen Species Activate a Ferritin-Linked TRPV4 Channel under a Static Magnetic Field

JOURNAL ARTICLE published 17 May 2024 in ACS Chemical Biology

Research funded by National Natural Science Foundation of China (32071237,32100031,51907192,51937011) | Institute of Electrical Engineering, Chinese Academy of Sciences (E155510101,E155510201)

Authors: Changyou Chen | Haitao Chen | Pingping Wang | Xue Wang | Xuting Wang | Chuanfang Chen | Weidong Pan

https://doi.org/10.1021/acschembio.4c00090 Actions

Introducing Our Authors

JOURNAL ARTICLE published 19 April 2024 in ACS Chemical Biology

Authors: Katie Nieves

https://doi.org/10.1021/acschembio.4c00182 Actions

Issue Publication Information

JOURNAL ARTICLE published 19 April 2024 in ACS Chemical Biology

https://doi.org/10.1021/cbv019i004_1793120 Actions

Issue Editorial Masthead

JOURNAL ARTICLE published 19 April 2024 in ACS Chemical Biology

https://doi.org/10.1021/cbv019i004_1793121 Actions

Discovery of a Tunable Heterocyclic Electrophile 4-Chloro-pyrazolopyridine That Defines a Unique Subset of Ligandable Cysteines

JOURNAL ARTICLE published 17 May 2024 in ACS Chemical Biology

Research funded by National Cancer Institute (ZIABC011961)

Authors: Hong-Rae Kim | David P. Byun | Kalyani Thakur | Jennifer Ritchie | Yixin Xie | Ronald Holewinski | Kiall F. Suazo | Mckayla Stevens | Hope Liechty | Ravichandra Tagirasa | Yihang Jing | Thorkell Andresson | Steven M. Johnson | Euna Yoo

https://doi.org/10.1021/acschembio.4c00025 Actions

Design, Synthesis, and Mechanistic Studies of (R)-3-Amino-5,5-difluorocyclohex-1-ene-1-carboxylic Acid as an Inactivator of Human Ornithine Aminotransferase

JOURNAL ARTICLE published 17 May 2024 in ACS Chemical Biology

Research funded by Division of Chemistry (1904480) | National Cancer Institute (R01 CA260250) | Centros de Pesquisa, Inova??o e Difus?o, Funda??o Amaz?nia Paraense de Amparo ? Pesquisa (2021/11205-9) | National Institute on Drug Abuse (P30 DA018310,R01 DA030604) | National Institute of General Medical Sciences (P41 GM108569)

Authors: Allison N. Devitt | Abigail L. Vargas | Wei Zhu | Benjamin James Des Soye | Fatma Ayaloglu Butun | Tyler Alt | Nicholas Kaley | Glaucio M. Ferreira | Graham R. Moran | Neil L. Kelleher | Dali Liu | Richard B. Silverman

https://doi.org/10.1021/acschembio.4c00022 Actions

Cytochrome P450 Mining for Bufadienolide Diversification

JOURNAL ARTICLE published 17 May 2024 in ACS Chemical Biology

Research funded by Program of Shanghai Subject Chief Scientist (21XD1401300) | National Key Research and Development Program of China (2018YFA0901900)

Authors: Xiaolai Lei | Xiaozheng Wang | Weiliang Xiong | Han Xiao | Yingchun Wu | Tingting Huang | Rubing Liang | Yiming Li | Shuangjun Lin

https://doi.org/10.1021/acschembio.4c00089 Actions

Lanmodulin’s EF 2–3 Domain: Insights from Infrared Spectroscopy and Simulations

JOURNAL ARTICLE published 17 May 2024 in ACS Chemical Biology

Research funded by Division of Chemistry (1945015) | Welch Foundation (F-1891) | National Institute of General Medical Sciences (R35GM133359)

Authors: Eman A. Alasadi | Wonseok Choi | Xiaobing Chen | Joseph A. Cotruvo | Carlos R. Baiz

https://doi.org/10.1021/acschembio.3c00789 Actions

Selection of Peptide–Bismuth Bicycles Using Phage Display

JOURNAL ARTICLE published 17 May 2024 in ACS Chemical Biology

Research funded by National Natural Science Foundation of China (22107066)

Authors: Ruo-Nan He | Meng-Jie Zhang | Bin Dai | Xu-Dong Kong

https://doi.org/10.1021/acschembio.4c00099 Actions

Discovery and Derivatization of Tridecaptin Antibiotics with Altered Host Specificity and Enhanced Bioactivity

JOURNAL ARTICLE published 17 May 2024 in ACS Chemical Biology

Research funded by Nederlandse Organisatie voor Wetenschappelijk Onderzoek (16440)

Authors: Nataliia V. Machushynets | Karol Al Ayed | Barbara R. Terlouw | Chao Du | Ned P. Buijs | Joost Willemse | Somayah S. Elsayed | Julian Schill | Vincent Trebosc | Michel Pieren | Francesca M. Alexander | Stephen A. Cochrane | Mark R. Liles | Marnix H. Medema | Nathaniel I. Martin | Gilles P. van Wezel

https://doi.org/10.1021/acschembio.4c00034 Actions

Craspase Orthologs Cleave a Nonconserved Site in Target Protein Csx30

JOURNAL ARTICLE published 17 May 2024 in ACS Chemical Biology

Research funded by H2020 European Research Council (101003229) | Nederlandse Organisatie voor Wetenschappelijk Onderzoek (VI.C.192.027)

Authors: Sam P. B. van Beljouw | Anna C. Haagsma | Konstantinos Kalogeropoulos | Martin Pabst | Stan J. J. Brouns

https://doi.org/10.1021/acschembio.3c00788 Actions

Virtual Screening of a Chemically Diverse “Superscaffold” Library Enables Ligand Discovery for a Key GPCR Target

JOURNAL ARTICLE published 19 April 2024 in ACS Chemical Biology

Research funded by National Institute on Drug Abuse (R01DA041435,R01DA045020) | National Institute of Mental Health (R01MH112205) | National Institute of General Medical Sciences (R01GM147537)

Authors: Katharina Grotsch | Anastasiia V. Sadybekov | Sydney Hiller | Saheem Zaidi | Dmitry Eremin | Austen Le | Yongfeng Liu | Evan Carlton Smith | Christos Illiopoulis-Tsoutsouvas | Joice Thomas | Shubhangi Aggarwal | Julie E. Pickett | Cesar Reyes | Elias Picazo | Bryan L. Roth | Alexandros Makriyannis | Vsevolod Katritch | Valery V. Fokin

https://doi.org/10.1021/acschembio.3c00602 Actions

Protein-Based Tools for Studying Neuromodulation

JOURNAL ARTICLE published 19 April 2024 in ACS Chemical Biology

Research funded by Division of Chemistry (CHE-2235835) | Gordon and Betty Moore Foundation (28431) | Camille and Henry Dreyfus Foundation (TC-23-084) | National Institutes of Health (DP2MH132939,R01DA053200,R21AG072009)

Authors: Wenjing Wang

https://doi.org/10.1021/acschembio.4c00037 Actions

Metabolic Investigation and Auxiliary Enzyme Modelization of the Pyrrocidine Pathway Allow Rationalization of Paracyclophane-Decahydrofluorene Formation

JOURNAL ARTICLE published 19 April 2024 in ACS Chemical Biology

Research funded by Chinese Government Scholarship (201808350098) | Sorbonne Universit? (ED406,SU-15-R-EMR-19-1)

Authors: Youwei Chen | Steffi Sewsurn | Séverine Amand | Caroline Kunz | Nicolas Pietrancosta | Kevin Calabro | Didier Buisson | Stéphane Mann

https://doi.org/10.1021/acschembio.3c00684 Actions

Phospholipids Differentially Regulate Ca2+ Binding to Synaptotagmin-1

JOURNAL ARTICLE published 19 April 2024 in ACS Chemical Biology

Research funded by Medical Research Council (MR/V028839/1) | Wellcome Trust (221795/Z/20/Z)

Authors: Sophie A. S. Lawrence | Carla Kirschbaum | Jack L. Bennett | Corinne A. Lutomski | Tarick J. El-Baba | Carol. V. Robinson

https://doi.org/10.1021/acschembio.3c00772 Actions

Reversible Covalent Inhibition─Desired Covalent Adduct Formation by Mass Action

JOURNAL ARTICLE published 19 April 2024 in ACS Chemical Biology

Authors: Disha Patel | Zil E Huma | Dustin Duncan

https://doi.org/10.1021/acschembio.3c00805 Actions
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